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Apr 13, 2004 ... Manometric study of topical sildenafil (Viagra) in patients with chronic anal fissure : sildenafil reduces anal resting tone. Torrabadella L(1) ...

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Topical therapies for anal fissure have largely focused on nitric-oxide donors (e. A beneficial effect of nitric oxide on the spastic anal sphincter has been demonstrated previously. Cet e-mail est protйgй contre les robots collecteurs de mails, votre navigateur doit accepter le javascript pour le voir femmes et hommes de 18 à plus de 60 ans, présentant des handicaps mentaux légers et moyens, des difficultés dadaptation sociale etou professionnelle ladmission est prononcée par le directeur de létablissement après décision dorientation de propose aux usagers une prise en charge diversifiée favorisant le plus dautonomie possible - hébergement et accompagnement au sein de structures évolutives (du foyer au studio) - ouverture sur lenvironnement par le biais dactivités, danimation et de lorganisation de séjours institutionnels ou avec des organismes agrées propose aux usagers, au travers dactivités diverses, un accompagnement adapté favorisant le bien être, la créativité et les liens interpersonnels effectue un suivi à domicile pour accompagner les usagers dans les actes de la vie quotidienne.

Topical administration of a phosphodiesterase-5 inhibitor (sildenafil, viagra) significantly reduces anal sphincter pressure in patients with chronic anal fissure. Time for initial relaxation (t1) and time to maximal relaxation (t2) were recorded. T2 230 - 78 seconds (m 271 - 63, f 183 - 75, p 0.

Average onset of action was less than three minutes, with maximum effect one minute later. This study confirms that this effect need not be derived solely from nitric oxide donors. New therapeutic avenues for treatment of anal fissure through indirect enhancement of nitric oxide activity are suggested.

Maximum resting pressure was repeated at the same distance from the anal verge. Topical phosphodiesterase inhibitors have theoretical merit but have never been reported in treatment of anal fissure. .

Station pullthrough manometry was performed with patients in the left-lateral position. This article describes manometric analysis of the effects of a phosphodiesterase-5 inhibitor, topical sildenafil (viagra) in 19 consecutive patients with chronic anal fissure with no previous treatment history. T1 168 - 67 seconds (m 210 - 72, f 130 - 53, p 0. Mild-to-moderate anal discomfort was reported by 26 percent of patients. Topical administration of 10 percent sildenafil was accompanied by significant reduction in anal sphincter pressure (18 percent p 0.


Topical Sildenafil (Viagra®) in the Treatment of Chronic Anal Fissure ...


Abstract: Topical Sildenafil (Viagra ® ) in the Treatment of Chronic Anal Fissure: A Randomized Double Blind Controlled Trial.

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    T1 168 - 67 seconds (m 210 - 72, f 130 - 53, p 0. Time for initial relaxation (t1) and time to maximal relaxation (t2) were recorded. This study confirms that this effect need not be derived solely from nitric oxide donors. T2 230 - 78 seconds (m 271 - 63, f 183 - 75, p 0. A beneficial effect of nitric oxide on the spastic anal sphincter has been demonstrated previously.

    Topical phosphodiesterase inhibitors have theoretical merit but have never been reported in treatment of anal fissure. Topical therapies for anal fissure have largely focused on nitric-oxide donors (e. Cet e-mail est protйgй contre les robots collecteurs de mails, votre navigateur doit accepter le javascript pour le voir femmes et hommes de 18 à plus de 60 ans, présentant des handicaps mentaux légers et moyens, des difficultés dadaptation sociale etou professionnelle ladmission est prononcée par le directeur de létablissement après décision dorientation de propose aux usagers une prise en charge diversifiée favorisant le plus dautonomie possible - hébergement et accompagnement au sein de structures évolutives (du foyer au studio) - ouverture sur lenvironnement par le biais dactivités, danimation et de lorganisation de séjours institutionnels ou avec des organismes agrées propose aux usagers, au travers dactivités diverses, un accompagnement adapté favorisant le bien être, la créativité et les liens interpersonnels effectue un suivi à domicile pour accompagner les usagers dans les actes de la vie quotidienne. Mild-to-moderate anal discomfort was reported by 26 percent of patients. Maximum resting pressure was repeated at the same distance from the anal verge.

    Topical administration of a phosphodiesterase-5 inhibitor (sildenafil, viagra) significantly reduces anal sphincter pressure in patients with chronic anal fissure. This article describes manometric analysis of the effects of a phosphodiesterase-5 inhibitor, topical sildenafil (viagra) in 19 consecutive patients with chronic anal fissure with no previous treatment history. Average onset of action was less than three minutes, with maximum effect one minute later. Topical administration of 10 percent sildenafil was accompanied by significant reduction in anal sphincter pressure (18 percent p 0. Station pullthrough manometry was performed with patients in the left-lateral position. New therapeutic avenues for treatment of anal fissure through indirect enhancement of nitric oxide activity are suggested. .

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